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Volume 119, Issue 3, Pages (September 2000)

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Presentation on theme: "Volume 119, Issue 3, Pages (September 2000)"— Presentation transcript:

1 Volume 119, Issue 3, Pages 774-781 (September 2000)
Magnetic resonance imaging and proton spectroscopic alterations correlate with parkinsonian signs in patients with cirrhosis  Laurent Spahr, François Vingerhoets, François Lazeyras, Jacqueline Delavelle, Renaud DuPasquier, Emile Giostra, Gilles Mentha, François Terrier, Antoine Hadengue  Gastroenterology  Volume 119, Issue 3, Pages (September 2000) DOI: /gast Copyright © 2000 American Gastroenterological Association Terms and Conditions

2 Fig. 1 MRI scan of a (A) healthy subject and (B) typical patient with cirrhosis showing pallidal hyperintensity. The BG and occipital WM voxels of interest used for MRS studies are framed in A. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

3 Fig. 2 T1-weighted MRI intensity (expressed as signal-to-noise ratio) of the different brain regions in patients with cirrhosis and mild HE (▩; n = 9), no HE (▨; n = 10), or in healthy subjects (□; n = 6). Values are presented as median and interquartile range. *P < 0.01 and **P < 0.05 vs. healthy subjects. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

4 Fig. 3 Spectra obtained at MRS in BG and occipital WM from a (A) typical patient with cirrhosis and (B) healthy subject. Arrows indicate abnormal metabolite ratios (Ino/Cr and Cho/Cr) in patients with cirrhosis. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

5 Fig. 4 Metabolite ratios obtained at MRS in (A) BG and (B) occipital WM in patients with cirrhosis and mild HE (▩; n = 9), no HE (▨; n = 10), or in healthy subjects (□; n = 6). Values are presented as median and interquartile range. *P < 0.02 vs. healthy subjects. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

6 Fig. 5 Correlation between UPDRS score and pallidal intensity (expressed as signal-to-noise ratio) in patients with cirrhosis (n = 18). Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

7 Fig. 6 Correlation between UPDRS score and Cho/Cr ratio in the BG in patients with cirrhosis (n = 18). Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

8 Fig. 7 Correlation between Purdue Pegboard score and Cho/Cr ratio in the BG in patients with cirrhosis (n = 18). Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions


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