1. 7. aDSM slides - Indicators of aDSM implementation and programme management
Multi-partner training package on active TB drug safety monitoring and management (aDSM)
July 2016

2. Learning objectives By the end of this presentation, the participant is expected to be able to…
Define the standard aDSM indicators for programme management

3. aDSM data serve a number of purposes
aDSM indicators (1)
aDSM data serve a number of purposes
Programme indicators
Causality assessment
Signal detection
Drug-safety profiles

4. aDSM indicators (2)
The programme manager needs measures of process and outcomes, especially in the early phases of implementing aDSM
This is besides the analyses needed for causality assessment and signal detection
Five indicators have been proposed to assess coverage and completeness of reporting, and the frequency of SAEs and confirmed ADRs

5. aDSM indicators (3) summary Class Indicator Coverage
MDR-TB patients on BDQ included in active PV
Completeness
Time to stopping BDQ
Serious adverse events
MDR-TB patients included in cohort event monitoring with any serious adverse event
BDQ-associated adverse reactions
Frequency of BDQ-associated ADRs
Time to development of BDQ-associated ADRs

6. aDSM indicators (4)

7. aDSM indicators (5)

8. aDSM indicators (6)

9. Table 11.5

10. WHO/HTM/TB/
This book presents the practicalities of standard and advanced analysis of programme TB surveillance data. The same approaches could have an application for in-depth analysis of aDSM data.
apps.who.int/iris/bitstream/10665/129942/1/ _eng.pdf