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Pathological alterations in idiopathic pulmonary fibrosis (IPF).

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Presentation on theme: "Pathological alterations in idiopathic pulmonary fibrosis (IPF)."— Presentation transcript:

1 Pathological alterations in idiopathic pulmonary fibrosis (IPF).
Pathological alterations in idiopathic pulmonary fibrosis (IPF). Lung biopsy of a patient with IPF showing the usual interstitial pneumonia pattern (haematoxylin–eosin–saffron stain; ×10 magnification; scale bar=500 µm). Fibrotic lung with microscopic honeycomb change (#) and remodelled arteries (arrows) is visible on the right, adjacent to preserved alveolar parenchyma on the left. Fibroblastic foci (arrowheads) are visible in between. A bronchiole is visible in the upper left corner of the micrograph. Laurent Plantier et al. Eur Respir Rev 2018;27:170062 ©2018 by European Respiratory Society

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Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Demystifying Idiopathic Interstitial Pneumonia Arch.

Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Demystifying Idiopathic Interstitial Pneumonia Arch.
A) High-resolution computed tomography scanning (case 1, 14 days prior to death) showing widespread ground glass opacification, faint nodules, thickening.

A) High-resolution computed tomography scanning (case 1, 14 days prior to death) showing widespread ground glass opacification, faint nodules, thickening.
Review of a patient with confirmed pulmonary veno-occlusive disease and nonmatched perfusion defects. a) Ventilation/perfusion lung scan with multiple.

Review of a patient with confirmed pulmonary veno-occlusive disease and nonmatched perfusion defects. a) Ventilation/perfusion lung scan with multiple.
Characteristics of advanced fibrosis in usual interstitial pneumonia of idiopathic pulmonary fibrosis include a subpleural distribution of fibrosis (A,

Characteristics of advanced fibrosis in usual interstitial pneumonia of idiopathic pulmonary fibrosis include a subpleural distribution of fibrosis (A,
Kaplan–Meier survival curves of interstitial pneumonia with autoimmune features (IPAF) with usual interstitial pneumonia (UIP) pattern (on high-resolution.

Kaplan–Meier survival curves of interstitial pneumonia with autoimmune features (IPAF) with usual interstitial pneumonia (UIP) pattern (on high-resolution.
Changes in high-resolution computed tomography (HRCT) pattern over time. a) Idiopathic pulmonary fibrosis (IPF), increased specificity over time. Changes.

Changes in high-resolution computed tomography (HRCT) pattern over time. a) Idiopathic pulmonary fibrosis (IPF), increased specificity over time. Changes.
Longitudinal imaging after initial diagnosis

Longitudinal imaging after initial diagnosis
Pathological changes in chronic obstructive pulmonary disease

Pathological changes in chronic obstructive pulmonary disease
Flow diagram of the systematic research method for detecting matching microRNAs (miRNAs) in systemic sclerosis (SSc) and idiopathic pulmonary fibrosis.

Flow diagram of the systematic research method for detecting matching microRNAs (miRNAs) in systemic sclerosis (SSc) and idiopathic pulmonary fibrosis.
High-resolution computed tomography (HRCT) features of interstitial lung abnormalities. a) HRCT of a 56-year-old patient whose mother died of idiopathic.

High-resolution computed tomography (HRCT) features of interstitial lung abnormalities. a) HRCT of a 56-year-old patient whose mother died of idiopathic.
Kaplan–Meier curve for the time until the development of lung cancer in patients with idiopathic pulmonary fibrosis. Kaplan–Meier curve for the time until.

Kaplan–Meier curve for the time until the development of lung cancer in patients with idiopathic pulmonary fibrosis. Kaplan–Meier curve for the time until.
Michael E. Halkos, MD, Anthony A. Gal, MD, Faraz Kerendi, MD, Daniel L

Michael E. Halkos, MD, Anthony A. Gal, MD, Faraz Kerendi, MD, Daniel L
Representative images of immunohistochemical staining of discoidin domain receptor (DDR)2 in interstitial lung disease (ILD) other than idiopathic pulmonary.

Representative images of immunohistochemical staining of discoidin domain receptor (DDR)2 in interstitial lung disease (ILD) other than idiopathic pulmonary.
Comparative expression of discoidin domain receptors (DDRs) between healthy lung tissues and those from different types of interstitial lung disease (ILD):

Comparative expression of discoidin domain receptors (DDRs) between healthy lung tissues and those from different types of interstitial lung disease (ILD):
A) Chest radiograph, b) multislice computed tomography angiography, c) three-dimensional magnetic resonance angiography, d) perfusion scintigraphy and.

A) Chest radiograph, b) multislice computed tomography angiography, c) three-dimensional magnetic resonance angiography, d) perfusion scintigraphy and.
Flowchart showing the requirement for starting, documenting and evaluating the effect on quality of life (QoL) of interdisciplinary best supportive care.

Flowchart showing the requirement for starting, documenting and evaluating the effect on quality of life (QoL) of interdisciplinary best supportive care.
Alveolar lymphangiogenesis is a feature of idiopathic pulmonary fibrosis (IPF). a) Tissue sections reacted with anti-D2-40 (brown) and anti-CD34 (red)

Alveolar lymphangiogenesis is a feature of idiopathic pulmonary fibrosis (IPF). a) Tissue sections reacted with anti-D2-40 (brown) and anti-CD34 (red)
Kaplan–Meier survival curves of all-cause mortality in patients with idiopathic pulmonary fibrosis (IPF). Kaplan–Meier survival curves of all-cause mortality.

Kaplan–Meier survival curves of all-cause mortality in patients with idiopathic pulmonary fibrosis (IPF). Kaplan–Meier survival curves of all-cause mortality.
A) Axial computed tomography (CT) showing mild thickening of bronchial walls (arrows) in a woman with Sjögren's syndrome. b) Chronic cough and recurrent.

A) Axial computed tomography (CT) showing mild thickening of bronchial walls (arrows) in a woman with Sjögren's syndrome. b) Chronic cough and recurrent.
High-resolution computed tomography scan revealing a nonspecific interstitial pneumonia pattern with basal predominant ground-glass opacities and associated.

High-resolution computed tomography scan revealing a nonspecific interstitial pneumonia pattern with basal predominant ground-glass opacities and associated.

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