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NAD+ Supplementation as a Novel Approach to cURIng HCC?

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Presentation on theme: "NAD+ Supplementation as a Novel Approach to cURIng HCC?"— Presentation transcript:

1 NAD+ Supplementation as a Novel Approach to cURIng HCC?
Ingmar Mederacke, Robert F. Schwabe  Cancer Cell  Volume 26, Issue 6, Pages (December 2014) DOI: /j.ccell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 The URI/NAD+ Pathway Can Be Targeted for the Prevention or Treatment of HCC Increased expression of URI in inflamed or injured liver leads to AhR- and/or ER-mediated reduction of NAD+, leading to DNA damage, which, in turn, triggers dysplasia, adenoma, and HCC development. Blocking URI, increasing AhR or ER activity, or restoring NAD+ levels can be employed for the prevention or treatment of HCC. Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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