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Published bySusanto Lesmono Modified over 6 years ago
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Exome-Wide Association Study of Pancreatic Cancer Risk
Robert C. Grant, Robert E. Denroche, Ayelet Borgida, Carl Virtanen, Natalie Cook, Alyssa L. Smith, Ashton A. Connor, Julie M. Wilson, Gloria Peterson, Nicholas J. Roberts, Alison P. Klein, Sean M. Grimmond, Andrew Biankin, Sean Cleary, Malcolm Moore, Mathieu Lemire, George Zogopoulos, Lincoln Stein, Steven Gallinger Gastroenterology Volume 154, Issue 3, Pages e3 (February 2018) DOI: /j.gastro Copyright © 2018 AGA Institute Terms and Conditions
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Figure 1 Power to detect a gene enriched for rare inactivating variants (RIVs) based on an empirical “spike-in” procedure. (A) Power at the exome-wide significance level. P < 2.5x10-6. (B) Power at the suggestive significance level P < .001. Gastroenterology , e3DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions
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Figure 2 Manhattan plots and quantile-quantile plots for gene-based case-control association analyses. (A) Rare inactivating variants (RIVs). (B) Rare damaging variants (RDVs). Gastroenterology , e3DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions
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