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Excitation BolsTORs Motor Neurons in ALS Mice

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Presentation on theme: "Excitation BolsTORs Motor Neurons in ALS Mice"— Presentation transcript:

1 Excitation BolsTORs Motor Neurons in ALS Mice
Mark P. Mattson  Neuron  Volume 80, Issue 1, Pages 1-3 (October 2013) DOI: /j.neuron Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Mechanisms by which Glutamate Receptor-Mediated Excitation May Protect Motor Neurons against SOD1 Mutations that Cause Inherited ALS CaMK, Ca2+/calmodulin-dependent protein kinase; CREB, cyclic AMP response element-binding protein; ER, endoplasmic reticulum; IL-1β, interleukin-1β; mTOR, mammalian target of rapamycin; NPP, neuroprotective proteins; SV, synaptic vesicle; TNFα, tumor necrosis factor α; VDCC, voltage-dependent Ca2+ channel. Neuron  , 1-3DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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