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Nicholas S. Coleman, Stephen Foley, Simon P

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1 Abnormalities of Serotonin Metabolism and Their Relation to Symptoms in Untreated Celiac Disease 
Nicholas S. Coleman, Stephen Foley, Simon P. Dunlop, Johanna Wheatcroft, Elaine Blackshaw, Alan C. Perkins, Gulzar Singh, Charles A. Marsden, Geoffrey K. Holmes, Robin C. Spiller  Clinical Gastroenterology and Hepatology  Volume 4, Issue 7, Pages (July 2006) DOI: /j.cgh Copyright © 2006 American Gastroenterological Association Terms and Conditions

2 Figure 1 Sections stained for 5-HT. (A) A few scattered EC cells in a normal biopsy specimen, and (B) markedly increased numbers of EC cells and crypt hyperplasia in a patient with celiac disease are shown. Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

3 Figure 2 The effect of a 520-kcal carbohydrate-rich test meal on plasma 5-HT levels in patients with celiac disease (n = 18) and healthy controls (n = 18). The dotted line represents the time the meal was started. Data are represented as means with standard errors. ●, Celiac patients; ○, healthy controls. Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

4 Figure 3 Individual peak postprandial plasma 5-HT levels in celiac patients (n = 18) and healthy controls (n = 18) after a 520-kcal carbohydrate-rich test meal. Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

5 Figure 4 Individual duodenal mucosal 5-HT levels in celiac patients (n = 17) and controls (n = 12) expressed per milligram of tissue protein. Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions


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