1. Update of the TCIA Imaging Data Pilot

2. TCIA Background

3. The Cancer Imaging Archive – Established 2010
Open access de-identified imaging data
Covers most modalities (CT/MR/PET/RT)
Wide variety of cancers + phantoms
Patient populations vary from a few to >26,000 (NLST)
Many have associated meta-data
Demographics/outcomes/therapy
Pathology histology imaging
Radiologist expert and AI analyses
‘Omics via TCGA, CPTAC, and GEO
Robust, multistep de-identifications for DICOM data and IRB approvals
TCGA: The Cancer Genome Atlas
GDC: Genomics Data Commons
CPTAC: Clinical Proteomic Tumor Analysis Consortium
GEO: Gene Expression Omnibus

4. Fully Public (no registration): 55 collections
Access
Fully Public (no registration): 55 collections
TCGA: 21
Phantom: 6
With associated metadata: 42
Limited access: 12 collections
Protect data while investigators are publishing results
Data collection for private or internal projects
Mechanism to request access
Limited data sets: QIN data sets: 6/10 limited
NSLT

5. A growing user community
33,000 total subjects in the archive
67 data sets currently available
21 from The Cancer Genome Atlas project
10 from the Quantitative Imaging Network
Clinical trial data from ECOG-ACRIN and RTOG
6 new data sets added/updated in 2016
363 publications based on TCIA data
70 new publications in 2016
As the network became richer and more known, with the connection to TCGA data, the publications have increased exponentially. NOTE: this is all we know about. Users are not obliged to tell us of publications and only professional ethics require that they acknowledge us.
81 of the 363 are NLST-related.  The detailed listing of those publications is stored here:     (TCIA links out to this page on its publication page)  These appear to all be peer-reviewed articles.
Of the 282 listed non-NLST publications, 62 are conference proceedings and the remainder are peer-reviewed journal articles.

6. A growing user community
TCIA now has over 4,000 active users per month

7. Apollo Pilot

8. Collaboration with Boston VA POP
Initial contacts in June & July before we knew about Apollo
Initiated discussions with Louis Fiore – initial plan:
Centralize imaging data at VA-MAVERIC –transfer images from medical centers on internal VA system.
Install TCIA client software if permitted (yes)
De-id and apply unique identifiers at VA-MAVERIC with TCIA assistance
Transfer Imaging data to TCIA, curate and post publicly
Curate and transfer clinical research CRF data to TCIA
Imaging data processed / analyzed by volunteer research groups
Analysis results made available on TCIA and added back to VA rePOP database
POP= Precision Oncology Program
MAVERIC Massachusetts Veterans Epidemiology Research and Information Center

9. After APOLLO meeting Aug 29
Proposed the small POP data set to be a pilot for data processes needed for APOLLO
Discussed with Fiore and his team on Aug 30
Identified the cases and key team members
31 cases fully consented (16 confirmed, 15 additional in pipeline)
IRB authorized
Medical images and histology images to go to TCIA
Genomic and clinical data to GDC (TCIA will support for Pilot)

10. TCIA Input System (Access restricted)
Imaging Workflow
3. Curation at MAVERIC (with TCIA assistance)
1.Imaging Data retrieved from PACS at VA Medical Centers
5. Secondary Review by TCIA
6. Data made publicly available to researchers
7.Quantitative Analysis (imaging linked by Master Patient ID to clinical data and genomics)
2. Moved to MAVERIC file system
4.Submission to TCIA
Site A
Apply Master patient ID
Apply Date offset
Remove known PHI
Visual Review
Private tag review
TCIA Input System (Access restricted)
Volume Analysis
Radiomics
Radiogenomics
TCIA Production
Site B
MAVERIC
Site C

11. Team members (Imaging Only)
TCIA: Freymann, Kirby, Jaffe, TCIA staff at UAMC
VA MAVERIC:
Louis Fiore, Executive Director
Dr. Valmeek (Vik) Kudesia – Director of Informatics
Luis E. Selva, Ph.D. – Health Informatics Systems
Samuel Ajjarapu, Saiju Parajan - Informatics
Dr. Andrew Zimolazk – MD/Informatician
Danne Elbers – Informatics Technical Lead

12. Cases will be processed as assembled, to shake out the bugs
Status 9/8/2016
CTP local installation being set up at the VA  MAVERIC  with an imaging workflow in place there
De-ID configuration draft: date offset and MasterCase ID to be applied across data types. 
Cases will be processed as assembled, to shake out the bugs
Anticipate first imaging case ready to send at VA MAVERIC in 2 weeks.
CTP+ RSNA MIRC Clinical Trials Processor

14. Sociology of data sharing?
Why no barriers at all should be erected to sharing

15. Lowering barriers to data access: easier to search
Sept removed the login requirement for accessing public data
Note that the previous login requirement was essentially anonomous
Still required for non- public data
Number of TCIA search queries (bi-weekly)
Chart shows number of searches performed bi-weekly

16. Lowering barriers to data access: made it easier to download
February 2016 simplified user interface added download buttons with each collection description.
Gigabytes Downloaded (bi-weekly)
For each collection that had a description – Chart shows Gbytes downloaded bi-weekly