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A Systematic Review and Meta-Analysis

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1 A Systematic Review and Meta-Analysis
Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis Tsipotis et al. Am J Nephrol 2016;44: (DOI: / ) Table 1. Characteristics of the bioequivalence crossover randomized controlled trials of healthy subjects included in the meta-analysis

2 A Systematic Review and Meta-Analysis
Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis Tsipotis et al. Am J Nephrol 2016;44: (DOI: / ) Table 1 (continued). Characteristics of the bioequivalence crossover randomized controlled trials of healthy subjects included in the meta-analysis

3 A Systematic Review and Meta-Analysis
Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis Tsipotis et al. Am J Nephrol 2016;44: (DOI: / ) Table 2. Characteristics of the parallel-arm randomized controlled trials included in the meta-analysis

4 A Systematic Review and Meta-Analysis
Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis Tsipotis et al. Am J Nephrol 2016;44: (DOI: / ) Fig. 1. Study selection flow diagram

5 A Systematic Review and Meta-Analysis
Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis Tsipotis et al. Am J Nephrol 2016;44: (DOI: / ) Fig. 2. Forest plot displaying the pooled weighted ratio of the T/R immunosuppressive drug for the mean Cmax with the corresponding 90% CI. ‘Test' refers to the generic immunosuppressive drug, and ‘reference' to its brand counterpart.

6 A Systematic Review and Meta-Analysis
Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis Tsipotis et al. Am J Nephrol 2016;44: (DOI: / ) Fig. 3. Forest plot displaying the pooled weighted ratio of the T/R immunosuppressive drug for the mean AUC(0-t), with the corresponding 90% CI. ‘Test' refers to the generic immunosuppressive drug, and ‘reference' to its brand counterpart.

7 A Systematic Review and Meta-Analysis
Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis Tsipotis et al. Am J Nephrol 2016;44: (DOI: / ) Fig. 4. Forest plot displaying the pooled weighted mean difference of the brand versus generic immunosuppressive drug for the mean Tmax, with the corresponding 95% CI. ‘Test' refers to the generic immunosuppressive drug, and ‘reference' to its brand counterpart.

8 A Systematic Review and Meta-Analysis
Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis Tsipotis et al. Am J Nephrol 2016;44: (DOI: / ) Fig. 5. Forest plot displaying the pooled weighted mean difference of the brand versus generic immunosuppressive drug for the mean T1/2, with the corresponding 95% CI. ‘Test' refers to the generic immunosuppressive drug, and ‘reference' to its brand counterpart.


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