1. Faster-Acting Insulins

3. Program Overview

4. Impact of Postprandial Hyperglycemia

5. Major Mechanisms Linking Elevated PPG to Diabetes Complications

6. Recommended Targets for PPG

8. Insulin Replacement Therapy Aims to Recreate the Normal Blood Insulin Profile

9. PK Profiles of Insulin Replacement Therapies

10. Faster-Acting Insulin: Approaching a More Exact Physiologic Insulin Profile

11. Effects of Hormone Signaling on Hepatic Glucose Metabolism

12. Faster Aspart: A New Formulation of Insulin Aspart

13. Faster Aspart vs Insulin Aspart via SC Injection: PK/PD Comparisons*

14. PK/PD Differences of Faster Aspart With CSII Are Even More Pronounced Than With SC Injections

15. PD Differences Between Faster Aspart and Insulin Aspart of Similar Magnitude Compared With Differences Between Insulin Aspart and RHI

16. Onset® Program for Faster Aspart

17. Onset® 1: Study Design

18. Onset® 1: Mean HbA1c Change From Baseline

19. Onset® 1: PPG Increment at Week 26

20. Onset® 1: Safety

21. Timing of Administration of Faster Aspart

22. Timing of Meal Insulin and Its Relation to Adherence to Therapy in T1DM

23. Practical Recommendations Regarding Timing of Administration

24. Other Faster-Acting Insulins in Development

25. Onset, Offset, and Overall Exposure of Faster Aspart vs Insulin Aspart in CSII

26. Onset® 4: A Trial Evaluating Compatibility and Safety of Faster Aspart and Insulin Aspart With an External CSII System in Adults With T1DM

27. Patients With T1DM Who May Be Candidates for Faster Aspart

28. 24-Year-Old Woman With T1DM

29. Onset® 2: Study Design

30. Onset® 2*: Mean Change in HbA1c Over Time

31. Onset® 2: PPG Increment (Meal Test) at Week 26

32. Onset® 2: Treatment-Emergent Hypoglycemia

33. Other Faster-Acting Insulins in Development (cont)

34. Patients With T2DM Who May Be Candidates for Faster Aspart

35. 58-Year-Old Man With T2DM for 8 Years

36. 58-Year-Old Man With T2DM for 8 Years (cont)

37. 58-Year-Old Man With T2DM for 8 Years (cont)

38. 58-Year-Old Man With T2DM for 8 Years (cont)

39. 58-Year-Old Man With T2DM for 8 Years (cont)

40. 60-Year-Old Woman With T2DM for 15 Years

41. 60-Year-Old Woman With T2DM for 15 Years (cont)

42. 60-Year-Old Woman With T2DM for 15 Years (cont)

43. 60-Year-Old Woman With T2DM for 15 Years (cont)

44. 60-Year-Old Woman With T2DM for 15 Years (cont)

45. Conclusions

46. Conclusions (cont)