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Adverse effects on insulin secretion of replacing saturated fat with refined carbohydrate but not with monounsaturated fat: A randomized controlled trial.

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Presentation on theme: "Adverse effects on insulin secretion of replacing saturated fat with refined carbohydrate but not with monounsaturated fat: A randomized controlled trial."— Presentation transcript:

1 Adverse effects on insulin secretion of replacing saturated fat with refined carbohydrate but not with monounsaturated fat: A randomized controlled trial in centrally obese subjects  Lin F. Chang, PhD, Shireene R. Vethakkan, MD, PhD, Kalanithi Nesaretnam, PhD, Thomas A.B. Sanders, PhD, Kim-Tiu Teng, PhD  Journal of Clinical Lipidology  Volume 10, Issue 6, Pages e1 (November 2016) DOI: /j.jacl Copyright © 2016 National Lipid Association Terms and Conditions

2 Figure 1 Consort diagram.
Journal of Clinical Lipidology  , e1DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions

3 Figure 2 Study design. (A) Outline of diet intervention. (B) Randomized diet allocation. Journal of Clinical Lipidology  , e1DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions

4 Figure 3 Postprandial C-peptide (A), insulin (B), glucose (C) and NEFA (D), GLP-1 (E), GIP (F), ghrelin (G), PYY (H), and CCK (I) responses after SAFA (white circle, solid line), CARB (white triangle, solid line), or MUFA (white square, dotted line) meals. n = 46 (34 women, 12 men). Change from preprandial value was significantly different for *CARB vs SAFA and MUFA meals (P < .05) and ΦCARB vs MUFA meals (P < .05). Insert: iAUC over 120 min (A–C and E–I) and 360 min (D). White bars, SAFA; black bars, CARB; striped bars, MUFA. σiAUC was significantly higher compared with SAFA and MUFA meals, P < .001 (A–D). Journal of Clinical Lipidology  , e1DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions

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