1. Carcinomas of lung
By: Shefaa’ Qa’qa’

2. important cause of cancer related deaths.
lung
Prostate
Breast

3. Smokers ?
Non smokers ?
Males
females

4. Small cell lung cancer (SCLC) Non–small cell lung cancer (NSCLC) Mets surgery chemotherapy?

6. Molecular changes:
EGFR
K-RAS
ALK
MET

7. Targeted therapy

8. Risk factors:
Environmental
Genetic/ P-450 monooxygenase enzyme system

9. Squamous cell carcinomas:
Men ? Women ?
Smoking ?
Centrally ? Peripherally ?
Mets ?
Cavitation (central necrosis) ?
Surgery ?
squamous metaplasia --- dysplasia --- carcinoma in situ

11. Adenocarcinomas:
Men ? Women ?
Smoking ?
Centrally ? Peripherally ?
Mets ?
Cavitation (central necrosis) ?
Surgery ?
Atypical adenomatous hyperplasia----
Adenocarcinoma in situ------
Minimally invasive adenocarcinoma-----
Invasive adenocarcinoma

13. Large cell carcinomas:
squamous cell
adenocarcinomas

14. Small cell lung carcinomas:
Centrally
Smoking
Mets
chemotherapy

16. Combined patterns

17. Virchow node
Vena caval syndrome
Horner syndrome/Apical tumors
Pancoast tumors

19. Paraneoplastic syndromes:
Hypercalcemia
Cushing syndrome
Syndrome of inappropriate secretion of antidiuretic hormone
Myasthenic syndrome
Polymyositis
Clubbing of the fingers and hypertrophic pulmonary osteoarthropathy
Coagulation abnormalities, including migratory thrombophlebitis and DIC

20. Carcinoid Tumors:
Typical (low-grade)
Atypical (intermediate-grade) carcinoid
Polypoid
Mucosal plaque penetrating the bronchial wall
Central
Peripheral
Only rarely do they induce the carcinoid syndrome, characterized
by intermittent attacks of diarrhea, flushing, and cyanosis