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Emerging LDL therapies: Mipomersen—antisense oligonucleotide therapy in the management of hypercholesterolemia  Peter P. Toth, MD, PhD, FAAFP, FICA, FNLA,

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Presentation on theme: "Emerging LDL therapies: Mipomersen—antisense oligonucleotide therapy in the management of hypercholesterolemia  Peter P. Toth, MD, PhD, FAAFP, FICA, FNLA,"— Presentation transcript:

1 Emerging LDL therapies: Mipomersen—antisense oligonucleotide therapy in the management of hypercholesterolemia  Peter P. Toth, MD, PhD, FAAFP, FICA, FNLA, FAHA, FCCP, FACC  Journal of Clinical Lipidology  Volume 7, Issue 3, Pages S6-S10 (May 2013) DOI: /j.jacl Copyright © 2013 National Lipid Association Terms and Conditions

2 Figure 1 Mechanism of action of an antisense oligonucleotide. DNA, deoxyribonucleic acid; mRNA, messenger ribonucleic acid. © Copyright Antisense Therapeutics Limited, Accessed at and reprinted with permission from Antisense Therapeutics Limited. Journal of Clinical Lipidology 2013 7, S6-S10DOI: ( /j.jacl ) Copyright © 2013 National Lipid Association Terms and Conditions

3 Figure 2 Change in LDL-C over time with 26 weeks of mipomersen treatment in a phase 3 trial in patients with homozygous FH. Reprinted with permission from Raal et al.11 LDL, low-density lipoprotein. Journal of Clinical Lipidology 2013 7, S6-S10DOI: ( /j.jacl ) Copyright © 2013 National Lipid Association Terms and Conditions

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