1. Message in a Biota: Gut Microbes Signal to the Circadian Clock
Emily V. Marcinkevicius, Mimi M. Shirasu-Hiza 
Cell Host & Microbe 
Volume 17, Issue 5, Pages (May 2015)
DOI: /j.chom
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1 Proposed Model for Diet-Induced Obesity
In this issue, Leone et al. (2015) demonstrate that in wild-type mice (upper panel), a high-fat diet affects diurnal oscillations of the gut microbiota and host circadian clock, both of which are known to regulate metabolism. They further confirm that, in the absence of the gut microbiota, germ-free mice (lower panel) have altered circadian clocks and are resistant to diet-induced obesity. Thus, they propose a model in which bi-directional interactions between the gut microbiota and the circadian clock in mice on a high-fat diet contribute to diet-induced obesity.
Cell Host & Microbe  , DOI: ( /j.chom )
Copyright © 2015 Elsevier Inc. Terms and Conditions