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Sickle Cell MicroRNAs Inhibit the Malaria Parasite

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Presentation on theme: "Sickle Cell MicroRNAs Inhibit the Malaria Parasite"— Presentation transcript:

1 Sickle Cell MicroRNAs Inhibit the Malaria Parasite
Manoj T. Duraisingh, Harvey F. Lodish  Cell Host & Microbe  Volume 12, Issue 2, Pages (August 2012) DOI: /j.chom Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Model for the Inhibition of Plasmodium falciparum Growth by Red Blood Cell miRNAs The P. falciparum parasite invades and grows within the host erythrocyte. Red blood cell miRNAs, enriched in sickle cells, translocate to the parasite cytoplasm, crossing over both the parasitophorous vacuolar membrane and the parasite plasma membrane. Within the parasite cytoplasm, the miRNAs are trans-spliced onto the 5′ ends of specific parasite mRNA transcripts, forming miRNA-mRNA chimeras. These chimeras are unable to be loaded onto polyribosomes or translated, resulting in the inhibition of parasite growth. Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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