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Volume 124, Issue 3, Pages (March 2003)

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Presentation on theme: "Volume 124, Issue 3, Pages (March 2003)"— Presentation transcript:

1 Volume 124, Issue 3, Pages 762-777 (March 2003)
Pathology of mouse models of intestinal cancer: Consensus report and recommendations  Gregory P. Boivin, Kay Washington, Kan Yang, Jerrold M. Ward, Theresa P. Pretlow, Robert Russell, David G. Besselsen, Virginia L. Godfrey, Tom Doetschman, William F. Dove, Henry C. Pitot, Richard B. Halberg, Steven H. Itzkowitz, Joanna Groden, Robert J. Coffey  Gastroenterology  Volume 124, Issue 3, Pages (March 2003) DOI: /gast Copyright © 2003 American Gastroenterological Association Terms and Conditions

2 Fig. 1 GIN from an AKR ApcMin/+ mouse.
Gastroenterology  , DOI: ( /gast ) Copyright © 2003 American Gastroenterological Association Terms and Conditions

3 Fig. 2 (A) Herniation of the intestinal mucosa of an Msh3−/− mouse. (B) Note the multiple cellular types in the invading cells and absence of a desmoplastic response in the herniated intestinal lesion. (C) Carcinoma in a Tgfb1−/− Rag2−/− mouse. (D) There is severe desmoplasia and loss of mucosa in the carcinoma. Gastroenterology  , DOI: ( /gast ) Copyright © 2003 American Gastroenterological Association Terms and Conditions

4 Fig. 3 Papillary adenoma from an ApcMin/+ mouse.
Gastroenterology  , DOI: ( /gast ) Copyright © 2003 American Gastroenterological Association Terms and Conditions

5 Fig. 4 Adenocarcinoma with mucinous differentiation in the small intestine of an Msh3−/− Apc1638/+ GEM. There is a strong desmoplastic reaction to the carcinoma. Gastroenterology  , DOI: ( /gast ) Copyright © 2003 American Gastroenterological Association Terms and Conditions

6 Fig. 5 A Tgfb1−/− Rag2−/− mouse with cecal mucinous adenocarcinoma. Large mucin lakes are present in the muscular wall. Gastroenterology  , DOI: ( /gast ) Copyright © 2003 American Gastroenterological Association Terms and Conditions

7 Fig. 6 Severe hyperplasia and inflammation in the colon of an IL-10−/− mouse. Gastroenterology  , DOI: ( /gast ) Copyright © 2003 American Gastroenterological Association Terms and Conditions

8 Fig. 7 (A) Multiple polyps in the colon of an AOM-treated mouse. (B) Carcinoma with severe desmoplasia in the colon of an AOM-treated mouse. Gastroenterology  , DOI: ( /gast ) Copyright © 2003 American Gastroenterological Association Terms and Conditions


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