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Siva Raja, MD, PhD, Thomas W. Rice, MD, John Ehrlinger, PhD, John R

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Presentation on theme: "Siva Raja, MD, PhD, Thomas W. Rice, MD, John Ehrlinger, PhD, John R"— Presentation transcript:

1 Importance of residual primary cancer after induction therapy for esophageal adenocarcinoma 
Siva Raja, MD, PhD, Thomas W. Rice, MD, John Ehrlinger, PhD, John R. Goldblum, MD, Lisa A. Rybicki, MS, Sudish C. Murthy, MD, PhD, David Adelstein, MD, Gregory Videtic, MD, Michael P. McNamara, MD, Eugene H. Blackstone, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 152, Issue 3, Pages e5 (September 2016) DOI: /j.jtcvs Copyright © Terms and Conditions

2 Figure 1 Predicted 3-year survival according to the percentage of residual primary cancer adjusted for all patient, cancer, and treatment characteristics. Red x's represent deaths and blue circles represent living or censored patients. The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

3 Figure 2 Predicted 3-year survival according to percentage of residual primary esophageal adenocarcinoma. The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

4 Figure 3 Partial dependence of 6-month, 1-year, and 3-year survival on residual primary cancer stratified by ypT classifications. Symbols are point estimates at 6 months (dots), 1 year (triangles), and 3 years (squares). The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

5 Figure 4 Partial dependence of 6-month, 1-year, and 3-year survival on residual primary cancer stratified by ypN classifications. Symbols are point estimates at 6 months (dots), 1 year (triangles), and 3 years (squares), with loess curves indicating trends. Note: ypN1 is 1 to 2 positive nodes, ypN2 is 3 to 6 positive nodes, and ypN3 is 7 or more positive nodes.15 The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

6 Figure 5 Relationship of the number of positive lymph nodes and residual primary cancer according to modality of induction therapy. The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

7 Figure E1 Distribution of residual primary cancer after induction therapy. The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

8 Figure E2 Risk-unadjusted survival after induction therapy and esophagectomy for adenocarcinoma of the esophagus. Each symbol represents a death, and vertical bars represent 68% confidence limits equivalent to ±1 standard error. The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

9 Figure E3 Variable importance of patient, cancer, and treatment characteristics for survival after esophagectomy. Blue bars represent a positive contribution to reducing prediction error, and red bars to the left of zero represent variables degrading prediction of survival. FEV1, Forced expiratory volume in 1 second; FVC, forced vital capacity; BMI, body mass index; SUV, standardized uptake value. The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

10 Figure E4 Variable importance of patient and cancer characteristics for residual primary cancer. Format is as in Figure E3. FVC, Forced vital capacity; SUV, standardized uptake value; BMI, body mass index; FEV1, forced expiratory volume in 1 second. The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

11 Predicted 3-year survival according to percentage of residual primary esophageal adenocarcinoma.
The Journal of Thoracic and Cardiovascular Surgery  , e5DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

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