1. Laboratory Practice Guidelines for Detecting and Reporting JAK2 and MPL Mutations in Myeloproliferative Neoplasms 
Jerald Z. Gong, James R. Cook, Timothy C. Greiner, Cyrus Hedvat, Charles E. Hill, Megan S. Lim, Janina A. Longtine, Daniel Sabath, Y. Lynn Wang 
The Journal of Molecular Diagnostics 
Volume 15, Issue 6, Pages (November 2013)
DOI: /j.jmoldx
Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2. Figure 1
Schematic representation of JAK2 gene and mutation hot spots. Locations of reported mutations are indicated by colored triangles: red triangles for V617F, black triangles for other SNP mutations, and blue triangles for insertions/deletions. Representative codon numbers are marked above exon boxes. FERM, four-point-one, ezrin, radixin, moesin domain; JH1, kinase domain; JH2, pseudokinase domain; SH2-like, SH2-like domain.
The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx )
Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3. Figure 2
Schematic representation of MPL gene and mutation hot spots. Locations of reported mutations are indicated by colored triangles: red triangles for W515L and W515K, and black triangles for other SNP variant mutations. Representative codon numbers are marked above exon boxes. CP, cytoplasmic domain; DCR-NRD, distal cytokine receptor domain-negative regulatory domain; PCR-LBR, proximal cytokine receptor domain-ligand binding region; TM, transmembrane domain.
The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx )
Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions