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Figure 3 Perimysial and muscle fiber pathology in HMGCR antibody–associated myopathy (A) Perimysial pathology with histiocytic cells and widening (hematoxylin.

Published byAmy Watson Modified over 6 years ago

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Presentation on theme: "Figure 3 Perimysial and muscle fiber pathology in HMGCR antibody–associated myopathy (A) Perimysial pathology with histiocytic cells and widening (hematoxylin."— Presentation transcript:

1 Figure 3 Perimysial and muscle fiber pathology in HMGCR antibody–associated myopathy (A) Perimysial pathology with histiocytic cells and widening (hematoxylin & eosin stain). Perimysial and muscle fiber pathology in HMGCR antibody–associated myopathy (A) Perimysial pathology with histiocytic cells and widening (hematoxylin & eosin stain). (B) Most cells in the perimysium are histiocytic and stain for acid phosphatase. (C) Muscle fibers at the edge of some fascicles are small and may be dark-stained (immature) (nicotinamide adenine dinucleotide stain). (D) Fragmentation of perimysial connective tissue (Gomori trichrome stain). (E) Cells in perimysial connective tissue are scattered, large, and irregularly shaped (nonspecific esterase stain). (F) Necrotic (dark) muscle fibers, with C5b-9 complement staining of cytoplasm, are scattered through the muscle but may have increased frequency at the edge of fascicles, a feature common in immune myopathies with perimysial pathology. C5b-9 complement is also deposited in perimysial connective tissue, occasionally extending into the endomysium. Scale bar = 100 μM for A, B, and D and 50 μM for C, E, and F. HMGCR = 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Ali Alshehri et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e124 © 2015 American Academy of Neurology

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