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Breathe in and Straighten Your Back: Hypoxia, Notch, and Scoliosis

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1 Breathe in and Straighten Your Back: Hypoxia, Notch, and Scoliosis
Lola Bajard, Andrew C. Oates  Cell  Volume 149, Issue 2, Pages (April 2012) DOI: /j.cell Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Hypothesis for a Gene-Environment Interaction Causing Congenital Scoliosis Environmental hypoxia (A), acting on a predisposing genotype (B), affects the segmentation clock that patterns somites (C), the precursors for vertebrae. This gene-environment interaction increases the severity and penetrance of the congenital scoliosis phenotype (D) that occurs sporadically in heterozygous mutants for genes of the Notch pathway. Cell  , DOI: ( /j.cell ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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