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William Insull, MD  The American Journal of Medicine 

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1 The Pathology of Atherosclerosis: Plaque Development and Plaque Responses to Medical Treatment 
William Insull, MD  The American Journal of Medicine  Volume 122, Issue 1, Pages S3-S14 (January 2009) DOI: /j.amjmed Copyright © Terms and Conditions

2 Figure 1 Histologic examples of 4 atherosclerotic plaque types. (A) Coronary fibrous cap atheroma in a 24-year-old man. (B) Thin fibrous cap atheroma. (C) Healed plaque rupture. (D) Stenosis of the anterior descending coronary artery in a 40-year-old man. (Reprinted with permission from Atlas of Atherosclerosis: Progression and Regression11 and Arterioscler Thromb Vasc Biol.12) The American Journal of Medicine  , S3-S14DOI: ( /j.amjmed ) Copyright © Terms and Conditions

3 Figure 1 Histologic examples of 4 atherosclerotic plaque types. (A) Coronary fibrous cap atheroma in a 24-year-old man. (B) Thin fibrous cap atheroma. (C) Healed plaque rupture. (D) Stenosis of the anterior descending coronary artery in a 40-year-old man. (Reprinted with permission from Atlas of Atherosclerosis: Progression and Regression11 and Arterioscler Thromb Vasc Biol.12) The American Journal of Medicine  , S3-S14DOI: ( /j.amjmed ) Copyright © Terms and Conditions

4 Figure 2 Increasing extent of atherosclerotic plaques with age. CVD = cardiovascular disease; LAD = left anterior descending. (Adapted with permission from Lab Invest.1) The American Journal of Medicine  , S3-S14DOI: ( /j.amjmed ) Copyright © Terms and Conditions

5 Figure 3 Flow chart of the general concepts of the development of atherosclerosis. ACS = acute coronary syndromes. (Adapted with permission from Arterioscler Thromb Vasc Biol.12) The American Journal of Medicine  , S3-S14DOI: ( /j.amjmed ) Copyright © Terms and Conditions

6 Figure 4 Influence of therapeutic intervention on the atherosclerotic process. The American Journal of Medicine  , S3-S14DOI: ( /j.amjmed ) Copyright © Terms and Conditions


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