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RNAi Delivers Insights into Liver Cancer

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Presentation on theme: "RNAi Delivers Insights into Liver Cancer"— Presentation transcript:

1 RNAi Delivers Insights into Liver Cancer
René Bernards  Cell  Volume 135, Issue 5, Pages (November 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Identifying Liver Cancer Tumor Suppressor Genes
High-resolution array comparative genome hybridization (CGH) of a panel of hepatocellular carcinomas allowed the identification of a number of genes in areas of recurrent copy number loss. Knockdown vectors delivering short hairpin RNAs (shRNAs) were generated against the murine orthologs of these candidate tumor suppressor genes. These vectors were then introduced into immortal but nontumorigenic murine hepatocytes and injected into mice. shRNAs capable of producing a tumorigenic phenotype are likely tumor suppressor genes in hepatocellular carcinoma. Cell  , DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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