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Catalytic Transfer Functionalization through Shuttle Catalysis

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Presentation on theme: "Catalytic Transfer Functionalization through Shuttle Catalysis"— Presentation transcript:

1 Catalytic Transfer Functionalization through Shuttle Catalysis
Bhawal, Benjamin N., Bill Morandi. ACS Catalysis, 2016,

2 1. Shuttle Catalysis Concept
2. Selected Examples of Shuttle Catalysis Reactions 3. Summary

3 1. Shuttle Catalysis Concept
2. 1. Shuttle Catalysis Concept 2. Scheme 1. Transfer Hydrogenation 1. Wang, Dong, Didier Astruc. Chemical reviews , 2015,

4 Scheme 2. Generalization of the Shuttle Catalysis Concept
Scheme 3. Definition of Forward and Reverse Shuttle Catalysis Reactions

5 2. Selected Examples of Shuttle Catalysis Reactions
Scheme 4. Metal−Organic Cooperatively Catalyzed Hydroacylation of Alkenes by Transfer of an Aldehyde 2. Jun, C.-H.; Lee, H. J. Am. Chem. Soc. 1999, 121, 880−881.

6 Scheme 5. Rhodium-Catalyzed Retro-hydroformylation of Aldehydes
3. Murphy, S. K.; Park, J.-W.; Cruz, F. A.; Dong, V. M. Science. 2015, 347, 56−60.

7 Scheme 6. Alkene Transfer Hydrocyanation, the Forward Process
4. Fang, X.; Yu, P.; Morandi, B. Science 2016, 351, 832−836.

8 Scheme 7. Retro-hydrocyanation, the Reverse Process
5. Lo, J. C.; Yabe, Y.; Baran, P. S. J. Am. Chem. Soc. 2014, 136, 1304−1307.

9 Scheme 8. Catalytic Transfer Hydromagnesiation
6. Shirakawa, E.; Ikeda, D.; Masui, S.; Yoshida, M.; Hayashi, T. J. Am. Chem. Soc. 2012, 134, 272−279.6.

10 Scheme 9. Catalytic Transfer Silacyclopropanation
7. Driver, T. G.; Woerpel, K. A. J. Am. Chem. Soc. 2003, 125, 10659−10663.

11 1. 金属催化的反应 2. 涉及烯烃作为受体或者供体,官能化或者去官能化 3. 可逆的反应过程,需要一定的驱动力


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