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Thyroid hormones: Possible roles in epilepsy pathology

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1 Thyroid hormones: Possible roles in epilepsy pathology
Seyedeh Masoumeh Seyedhoseini Tamijani, Benyamin Karimi, Elham Amini, Mojtaba Golpich, Leila Dargahi, Raymond Azman Ali, Norlinah Mohamed Ibrahim, Zahurin Mohamed, Rasoul Ghasemi, Abolhassan Ahmadiani  Seizure - European Journal of Epilepsy  Volume 31, Pages (September 2015) DOI: /j.seizure Copyright © 2015 British Epilepsy Association Terms and Conditions

2 Fig. 1 Schematic representation of how THs regulate mitochondrial function (biogenesis, oxygen consumption, and gene expression) affecting nuclear and/or mitochondrion genome (direct and indirect pathways). Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2015 British Epilepsy Association Terms and Conditions

3 Fig. 2 Schematic representation of the possible interactions between the thyroid and GABA systems in vertebrates. The + and − symbols indicate stimulation and inhibition, respectively. GABA, γ-aminobutyric acid; TRH, thyrotropin releasing hormone; TSH, thyroid stimulating hormone; T3, triiodothyronine; T4, thyroxine. Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2015 British Epilepsy Association Terms and Conditions


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