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A New Chapter in the Life of Cajal’s Short-Axon Neurons: Separation of Interneuron Siblings after Birth  Cristina Gil-Sanz, Ulrich Müller  Neuron  Volume.

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Presentation on theme: "A New Chapter in the Life of Cajal’s Short-Axon Neurons: Separation of Interneuron Siblings after Birth  Cristina Gil-Sanz, Ulrich Müller  Neuron  Volume."— Presentation transcript:

1 A New Chapter in the Life of Cajal’s Short-Axon Neurons: Separation of Interneuron Siblings after Birth  Cristina Gil-Sanz, Ulrich Müller  Neuron  Volume 87, Issue 5, Pages (September 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Interneuron Generation and Dispersion in the Neocortex
(A) Cortical interneurons born in the MGE migrate tangentially into the cortex following two migratory streams. Early-born neurons (blue) migrate through the marginal zone (MZ) and late-born neurons (orange) follow a deeper pathway through the intermediate zone (IZ) and the subventricular zone (SVZ). After reaching the cortex, the interneurons migrate radially to find their correct laminar position. (B) Scheme of the proliferative zone of the MGE displaying the different types of interneuron progenitors described to date. Radial glial cells (RGCs) divide and generate intermediate progenitors (IPCs), short neural progenitors (SNPs), and subapical progenitors (SAPs). These progenitors generate interneurons (INs). (C) Schematic representation of the strategy to analyze the distribution of clonally related interneurons. Low titer retrovirus injections target single or low numbers of interneuron progenitors in the MGE. The relative position of clonally related sibling neurons generated from the progenitors can be determined in the mature cortex. Neuron  , DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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