1. LIFE: Reduction in primary end-point events seen with reduction of LVH by two electrocardiographic criteria
End point
% reduction with each 1050-mm x ms [1 SD] decrease in Cornell product
Hazard ratio (95% CI)
% reduction with each 10.5-mm [1 SD] decrease in Sokolow-Lyon voltage
CV death, nonfatal MI, nonfatal stroke 14
0.86
( )* 17
0.83
( )*
*p<0.001
Okin PM et al. JAMA 2004; 292:

2. LIFE: Risk of composite end point with regression of LV mass index
Hazard ratio (95% CI) per 1 SD (25.3) in LV mass index p
CV death, MI or stroke
0.78 ( )
0.009
Devereux RB et al. JAMA 2004; 292: