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Neuronal Inhibition under the Spotlight

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Presentation on theme: "Neuronal Inhibition under the Spotlight"— Presentation transcript:

1 Neuronal Inhibition under the Spotlight
Martin Mortensen, Trevor G. Smart  Neuron  Volume 88, Issue 5, Pages (December 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Photo-inhibition of α1T125Cβ2γ2 GABAA Receptor by a Tethered PTL (A) PTLs are composed of three linked modules: a cysteine reactive maleimide; a photoswitchable azobenzene; and a GABA (guanidinium derivative) ligand. (B) Homology model of α1β2γ2 showing the interfacial GABA binding site with binding loops A (red), B (blue), and C (orange) from the principal (+) β2 subunit and loops D (cyan), E (purple), and F (green) from the complementary (−) α1 subunit. Both α1T125C and the PTL are shown in yellow. (Ba) In this example, the cis form of the PTL does not enter the GABA binding site; however, when photoswitched by 500 nm light into the trans isomer (Bb), the ligand-group accesses the binding site displacing GABA and causing inhibition. Light at 380 nm reverts the PTL back to its cis form relieving inhibition. Neuron  , DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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