1. PowerLecture: Chapter 12
Chromosomes and Human Inheritance

2. Philadelphia Chromosome
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3. Sex Chromosomes __________________________ __________________
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4. Karyotype Preparation
Fig. 12-3a-e, p.189

5. Karyotype Diagram
Fig. 12-3f, p.189

6. Autosomal Dominant Inheritance
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Fig a, p. 190

7. Autosomal Dominant Inheritance example… __________________
Fig. 12-5, p.190

8. Achondroplasia
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9. Huntington Disorder ________________________________
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10. Autosomal Recessive Inheritance Patterns
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Fig b, p. 191

11. Galactosemia _______________________________
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lactose
galactose
enzyme 1
+ glucose
galactose-1-
phosphate
enzyme 2
galactose-1-
phosphate
enzyme 3
intermediate
in glycolysis

12. Hutchinson-Gilford Progeria
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13. The Y Chromosome ________________________________
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14. The X Chromosome ___________________________
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15. Thomas Morgan ______________________
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16. Examples of X-Linked Traits
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17. Duplication ______________________________________________

18. Duplication
normal chromosome
one segment
repeated
three repeats

19. Deletion
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20. Inversion __________________ In-text figure Page 196 segments
G, H, I become inverted
In-text figure Page 196

21. Translocation
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22. Translocation one chromosome In-text figure Page 206 a nonhomologous
nonreciprocal translocation
In-text figure Page 196

23. Duplications & Translocations
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Fig , p.197

24. Chromosome Structure ______________________________________________
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25. Chromosome Structure _______________
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26. Chromosome Structure human chimpanzee gorilla orangutan
Fig , p.197

27. Aneuploidy
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28. Polyploidy
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29. Nondisjunction n + 1 n + 1 n - 1 n - 1
chromosome alignments at metaphase I
NONDISJUNCTION AT ANAPHASE I
alignments at metaphase II
anaphase II
CHROMOSOME
NUMBER IN
GAMETES
Fig b, p.198

30. Nondisjunction
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31. Down Syndrome
Fig , p.199

32. Nondisjunction
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33. Fig b,p.200

34. Phenotypic Treatments
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35. Genetic Screening ______________________________________________
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36. Preimplantation Diagnosis
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