1. Preservation of Pharma Products in a Cold Storage
Gubba Prashanth,
Innovations & Technical Head

2. Introduction

3. Critical Aspects in a Pharma Cold Storage
Design & Construction
Refrigeration
Quality & Operational Controls
Safety

4. Refrigeration Frozen: -20°C (4°F). Cold: 2°-8°C
Cool: Store between 8°-15°C (45°-59°F).
Room temperature: Store at 15°-25°C (59°-77°F).
Ambient temperature: 25°C and above

5. Refrigeration
Geo Thermal
Peltier

6. Automation of Refrigeration Plant

7. Design & Construction
Solar power

8. Material Handling System
Design & Construction
Material Handling System

9. Material Handling System
Design & Construction
Material Handling System
- Block Stacking
- Racking
- Single deep
- Drive in
- Double deep
- Satellite racking
- Push back
- Mobile racking
- ASRS

10. Quality & Operational Controls
Temperature Mapping

11. Quality & Operational Controls
Online temperature

13. Quality & Operational Controls
21 CFR

14. Mean Kinetic Temperature
MKT or Mean Kinetic Temperature gives a far better representation of the effects of temperature change on sensitive materials such as seeds during storage and distribution. In many instances it can be shown that the ‘shelf life’ of sensitive materials is directly related to the MKT. Mean Kinetic Temperature can be calculated from a series of temperatures. It differs from other means (such as a simple numerical average or arithmetic mean) in that higher temperatures are given greater weight in computing the average.

15. Mean Kinetic Temperature

16. Quality & Operational Controls
Thermal Tracking

17. Quality & Operational Controls
Rodent Management

18. Web enabled SMS alerts Auditing
Quality & Operational Controls
Inventory management
Web enabled
SMS alerts
Auditing

19. Safety Auditing Safety Culture
Quality & Operational Controls
Safety Management
Safety Auditing
Safety Culture

20. Quality & Operational Controls
Certifications
GDP
ISO GC
OSHAS
HACCP

21. Quality & Operational Controls
QC Team

22. To Conclude
Improve

23. Thank You