1. Benson Otarigho 1&2 & Mofolusho O. Falade 2
Identification and Characterization of Sodium and Chloride-dependent Gamma-aminobutyric Acid (GABA) Transporters in Eukaryotic Pathogens
Benson Otarigho 1&2 & Mofolusho O. Falade 2
Department of Biological Science, Edo University, Iyamho, Edo State, Nigeria.
2. Cellular Parasitology Programme, Department of Zoology, University of Ibadan, Nigeria.
1.0 Introduction
2.0 Materials and methods
Our study successfully identified most of these parasite GABA transporters for the first time from parasite genomes that are publically available in known databases. These proteins were characterized by subjecting them to phylogenetic analyses. This work can also lay basics for understanding of the function and mechanism of GABA transporters in these pathogens. The evolutionary position, history and relationship of these proteins can also help in knowing the transporters that have a more similar structure and functions which could be vital in the development chemotherapy. The findings in this study suggest that GABA transporters could offer new and alternative possibilities for potential drug development against most parasitic diseases affecting both man and animals.
4.0 Conclusion
3.0 Results and Discussion
5.0 References
Parsons, M.B. et al., PLoS Negl Trop Dis, 9(2), p.e
Torrey, E.F. et al., Schizophrenia research, 165(1), pp.1-2.
Cook, C.J Review of Economics and Statistics 97.4 (2015):
Pundir S.M. et al Current Protocols in Bioinformatics. pp
Steinbiss, S. et al Nucleic Acids Res, vol. 44, no. 1, pp. W29-W34, 2016.
Comitani, F. et al., Journal of chemical theory and computation, 12(7), pp
Chua, H.C. and Chebib, M., Advances in Pharmacology.
6.0 Acknowledgement
Thanks to the following Institutions/Organizations for their support
Infectious diseases such as malaria, trypanosomiasis, leishmaniasis, schistosomiasis have huge health, social and economic impact on major populations particularly in endemic regions (Parsons et al., 2015). They are responsible for a high degree of morbidity and mortality. Globally, about 50% of deaths attributed to these diseases occur among the poorest countries of the world (Fuller et al., 2015). In addition, some of these pathogens infect domestic and wild animals, consequently, leading to zoonotic infections (Cook, 2015). Although several drugs have been developed against most of these infectious diseases, there are emergence of resistant strains for some and a lack of vaccines for most of these parasites particularly the most economically important ones (Pundir et al., 2015). Therefore, there is a necessity to develop new drugs, identify novel drug targets to help in control efforts (Steinbiss et al., 2016). The genomic sequences of parasitic diseases are rapidly becoming available with the promise of the identification of new drug targets and novel chemotherapeutic treatments for the control of parasitic diseases. One of such targets is GABA transporter that is the main inhibitory neurotransmitter belong to a family of neurotransmitter:sodium symporters (Comitani, et al., 2016; Ecker et al., 2017). Hence, the aim of this work is to identify, characterize and analyse sodium and chloride-dependent gamma-aminobutyric acid (GABA) transporters of eukaryotic pathogens from microbe genomes.
Identification and Characterization of Sodium and Chloride-dependent Gamma-aminobutyric Acid (GABA) Transporters in Eukaryotic Pathogens by Benson Otarigho & Mofolusho O. Falade is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License