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Ovarian germline stem cells: an unlimited source of oocytes?
Carol B. Hanna, Ph.D., Jon D. Hennebold, Ph.D. Fertility and Sterility Volume 101, Issue 1, Pages (January 2014) DOI: /j.fertnstert Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 The spatial arrangement of the germline stem cell (GSC) niche in Drosophila. The GSC niche is composed of the somatic cells that include those in the terminal filament and cap cells, which provide signals necessary for GSC self-renewal. Fertility and Sterility , 20-30DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 The spatial arrangement of the germline stem cell (GSC) niche in Caenorhabditis elegans. Mitotic GSCs are in close proximity to the distal cap cell, the somatic cell responsible for maintaining adjacent cells in an undifferentiated state. Once GSCs are several cell layers removed from the distal cap cells, they differentiate and undergo meiosis. Fertility and Sterility , 20-30DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions
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Figure 3 The spatial arrangement of the germline stem cell (GSC) niche in medaka. GSCs reside in the germinal epithelium, a region that lies in between the basement membrane and the epithelial cells. GSC maintenance and renewal is regulated by adjacent Sox9b-expressing somatic cells. Fertility and Sterility , 20-30DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions
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