1. Chapter 3 Administration of Aerosolized Agents
RES 219
Pharmacology

2. Aerosolized medications
Advantages of aerosols
Disadvantages of aerosols

3. Definitions:
Aerosol
Stability
Penetration
Deposition

4. Aerosol Particle Size 10-15 microns 5-10 microns 1-5 microns
Factors determining particle size
Breathing Pattern
Inertial impaction

8. Aerosol Delivery Devices
Ultrasonic nebulizer
Small particle aerosol generator
Small volume nebulizer
Filling volume/treatment time
Effect of flow rate
Gas sources

12. Relationship of vol. & flow rate to neb time

13. Effect of Flow Rate on particle size

14. Nebulizer Designs Constant output Breath activated
Vibrating mesh technology
Breath enhanced
Adaptive aerosol delivery

20. Metered-Dose Inhaler Propellants used in MDI Advantages of MDI
Disadvantages of MDI
Proper use of MDI

23. CFC vs. HFA

24. Reservoir Devices
Spacer
Holding chamber
Advantages of reservoirs

25. Reservoir Device

27. Other Inhalers Breath-actuated inhaler Dry-powder inhaler
Soft mist inhaler

28. Breath-actuated Inhaler

29. DPI

31. Soft Mist Inhaler

32. What method of delivery is best?
MDI vs SVN vs DPI vs SMI??

33. Aerosol loss for 4 drug delivery systems

34. Comparison of lung deposition of older vs new aerosol devices

35. Lung deposition & clinical response: Comparison of 3 bronchodilator delivery methods

36. Infection Control Patient education on cleaning of Jet nebulizer MDI
Reservoir devices

37. Administration of aerosol via ET tube
MDI vs SVN
Factors the affect aerosol deposition in mechanical vent
Techniques for MDI & SVN via vent