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Volume 12, Issue 8, Pages (August 2011)

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1 Volume 12, Issue 8, Pages 763-772 (August 2011)
Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study  Prof Tom Treasure, MD, Loic Lang-Lazdunski, MD, David Waller, FRCS [CTh], Prof Judith M Bliss, MSc, Carol Tan, FRCS [CTh], James Entwisle, FRCR, Michael Snee, DM, Mary O'Brien, MD, Gill Thomas, FRCR, Prof Suresh Senan, FRCR, Prof Ken O'Byrne, MD, Lucy S Kilburn, MSc, James Spicer, MRCP, David Landau, FRCR, John Edwards, FRCS [CTh], Gill Coombes, RGN, Liz Darlison, RGN, Prof Julian Peto, DSc  The Lancet Oncology  Volume 12, Issue 8, Pages (August 2011) DOI: /S (11) Copyright © 2011 Elsevier Ltd Terms and Conditions

2 Figure 1 Trial design BTS=British Thoracic Society. MARS=Mesothelioma and Radical Surgery. EPP=extra-pleural pneumonectomy. The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions

3 Figure 2 Feasibility of registration and recruitment to MARS
Numbers in brackets indicate those patients screened who did not have chemotherapy before registration. MARS=Mesothelioma and Radical Surgery. MDT=multidisciplinary team. EPP=extra-pleural pneumonectomy. The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions

4 Figure 3 Feasibility of EPP surgery and radical radiotherapy treatment
EPP=extra-pleural pneumonectomy. *Subsequent perioperative death. †Other complications were flexible bronchoscopy or drain infection in pneumonectomy cavity; ischaemic right leg requiring femoropopliteal bypass and eventual below knee amputation with culture-positive pneumonia needing mini tracheostomy. ‡Postoperative pain, low blood pressure, and intraoperative bleeding and further bleeding from chest drains postoperatively. The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions

5 Figure 4 Overall survival EPP=extra-pleural pneumonectomy.
The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions

6 Figure 5 Recurrence-free and progression-free survival
Recurrence-free survival in patients randomised to EPP (A) and progression-free survival in patients randomly assigned to no EPP (B). EPP=extra-pleural pneumonectomy. The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions

7 Figure 6 Quality of life The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions


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