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Pharmacologic Modulation of Human Immunity in the Era of Immuno-oncology: Something Old, Something New Anagha Bangalore Kumar, MBBS, Rachel Maus, PhD, Svetomir N. Markovic, MD, PhD Mayo Clinic Proceedings Volume 93, Issue 7, Pages (July 2018) DOI: /j.mayocp Copyright © 2018 Mayo Foundation for Medical Education and Research Terms and Conditions
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Figure 1 The action of cytotoxic T-lymphocyte–associated protein (CTLA) inhibitors. Ipilimumab is an anti–CTLA-4 antibody that causes blockade of CTLA-4, resulting in prolonged T-cell activation, proliferation, and antitumor response. Mayo Clinic Proceedings , DOI: ( /j.mayocp ) Copyright © 2018 Mayo Foundation for Medical Education and Research Terms and Conditions
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Figure 2 The action of anti–programmed cell death 1 (PD-1) and anti–programmed death ligand-1 (PD-L1) blockers. Mayo Clinic Proceedings , DOI: ( /j.mayocp ) Copyright © 2018 Mayo Foundation for Medical Education and Research Terms and Conditions
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Figure 3 The concept of adoptive cell therapy.
Mayo Clinic Proceedings , DOI: ( /j.mayocp ) Copyright © 2018 Mayo Foundation for Medical Education and Research Terms and Conditions
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