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Genome-Wide Association Study Identifies Risk Variants for Lichen Planus in Patients With Hepatitis C Virus Infection Yumiko Nagao, Nao Nishida, Licht Toyo-oka, Atsushi Kawaguchi, Antonio Amoroso, Marco Carrozzo, Michio Sata, Masashi Mizokami, Katsushi Tokunaga, Yasuhito Tanaka Clinical Gastroenterology and Hepatology Volume 15, Issue 6, Pages e5 (June 2017) DOI: /j.cgh Copyright © 2017 AGA Institute Terms and Conditions
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Figure 1 Clinical presentations of lichen planus. (A) Lower lip, (B and D) left buccal mucosa, (C) tongue. Clinical Gastroenterology and Hepatology , e5DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions
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Figure 2 Genome-wide view of the single-point association data based on allele frequencies in a comparison of 71 HCV Japanese patients with LP and 190 patients with HCV without OLP. P values were calculated using the chi-square test for allele frequencies among 629,553 SNPs. Clinical Gastroenterology and Hepatology , e5DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions
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Supplementary Figure 1 Principal component analysis of 261 studied samples together with HapMap samples (including 43 JPT, 40 CHB, 91 YRI, and 91 CEU samples). Clinical Gastroenterology and Hepatology , e5DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions
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Supplementary Figure 2 Quantile-Quantile plot of the allele-based Chi-square test statistics for the GWAS results. The dots represent the P values of each SNP that passed the quality control filters. The inflation factor λ was estimated to be for all the tested. Clinical Gastroenterology and Hepatology , e5DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions
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Supplementary Figure 3 Regional Manhattan plot of the HLA class II region (Chr6: 32,256, ,258,648, GRCh37 hg19) in the GWAS. Clinical Gastroenterology and Hepatology , e5DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions
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Supplementary Figure 4 High density association mapping based on genotype imputation around (A) rs884000, and (B) rs Clinical Gastroenterology and Hepatology , e5DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions
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