1. IL-15

2. IL-15 activation of T-cell, Φ, fibroblast in synovium of RA
Angiostatic
IL-12, IFN-a b g, PF4
activation of T-cell, Φ, fibroblast in synovium of RA
Angiogenesis
VEGF, FGF, HGF
IL-8, angipoietin-1
Stromal cell derived GF
TNF, TGF (indirect)
Adhesion molecules
ICAM-1,2
VAM-1
*b-integrin
LAF-3
*P-selectin
AMG : IL-15 human monoclonal Ab
BMP
MIF
IL-15
IL-15
T-cell migration
IL-15
TNF-a
IL-1
IL-6
IL-7
IL-8
IL18
MIF
angiopoietin-1
SDGF, FGF
IL-1
TNF-a
GM-CSF
IL-6
MIF
IL-12
IL-18
IgG
IFN-g
IL-2
IL-4
IL-6
IL-5
IL-17
MIF B
MIF
proliferation & resist to apoptosis
IL-15
effector
T-cells
MMP
IL-15
IL-18 T
T1,2 K Tc
NK-IFN-g
IFN-g
IL-2
CD40
ligand
IL-15
 TNF-a production by Φ -- contact dependent with CD 40L (CD154)