1. The surgeon's role in molecular biology
Gaetano Rocco, MD, FRCSEd, FECTS 
The Journal of Thoracic and Cardiovascular Surgery 
Volume 144, Issue 3, Pages S18-S22 (September 2012)
DOI: /j.jtcvs
Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

2. Figure 1
Genetic foundations of individualized therapy. AMG102, humanized monoclonal anti-HGF IgG; EML4-ALK, echinoderm microtubule-associated protein-like 4/anaplastic lymphoma kinase; IGF-1R, insulin-like growth factor 1 receptor; IMC-AT2, cixutumumab (humanized recombinant IgG1/λ monoclonal antibody); MET, mesenchymal to epithelial transition; PTEN, phosphatase and tensin homolog; TSG1/2, tumor suppressor gene 1/2; VEGF, vascular endothelial growth factor; VEGFR, VEGF receptor.
Reprinted with permission from Janku and colleagues.15
The Journal of Thoracic and Cardiovascular Surgery  , S18-S22DOI: ( /j.jtcvs )
Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

3. Figure 2
Sequential superimposed genetic abnormalities leading to carcinogenesis (adenocarcinoma). LOH, Loss of heterozygosity.
Reprinted with permission from Noguchi and colleagues.12
The Journal of Thoracic and Cardiovascular Surgery  , S18-S22DOI: ( /j.jtcvs )
Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

4. Figure 3
The role of the thoracic surgeon in the biomolecular era. EBUS, Endobronchial ultrasonography; EEUS, endoscopic esophageal ultrasonography; VATS, video-assisted thoracic surgery.
The Journal of Thoracic and Cardiovascular Surgery  , S18-S22DOI: ( /j.jtcvs )
Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions