1. Trypanosomes We will discuss two groups.
African group (transmitted by tsetse flies belonging to the genus Glossina)
New World (transmitted by bugs)

2. African Sleeping Sickness
The Trypanosoma brucei group.
T. brucei brucei
T. brucei gambiense
T. brucei rhodesiense

3. T. b. brucei
Occurs in the circulatory system of most native antelopes, ruminants, and other wildlife in Africa.

4. T. b. brucei Non-pathogenic to these animals (does not kill them!).
Occurs in the circulatory system of most native antelopes, ruminants, and other wildlife in Africa.
Non-pathogenic to these animals (does not kill them!).

5. T. b. brucei
Occurs in the circulatory system of most native antelopes, ruminants, and other wildlife in Africa.
Non-pathogenic to these animals (does not kill them!).
However it is fatal to introduced livestock like cattle, causing a wasting disease called Nagana.

6. Nagana caused by T. b. brucei

7. Resistant Breeds of Cattle

8. T. b. gambiense: Chronic or Gambian Sleeping Sickness
Occurs in people.

9. T. b. gambiense: Chronic or Gambian Sleeping Sickness
Occurs in people.
Fatal if not treated.

10. T. b. gambiense: Chronic or Gambian Sleeping Sickness
Occurs in people.
Fatal if not treated.
Chronic infections (low-level infection that last a long time).

11. T. b. gambiense: Chronic or Gambian Sleeping Sickness
Occurs in people.
Fatal if not treated.
Chronic infections (low-level infection that last a long time).
Does not occur in either native animals or livestock.

12. T. b. gambiense: Chronic or Gambian Sleeping Sickness
Occurs in people.
Fatal if not treated.
Chronic infections (low-level infection that last a long time).
Does not occur in either native animals or livestock.
It is transmitted from person to person by the Tsetse fly.

13. T. b. rhodesiense: Acute or Rhodesian Sleeping Sickness
Causes acute infections in people.

14. T. b. rhodesiense: Acute or Rhodesian Sleeping Sickness
Causes acute infections in people.
Usually fatal within a year.

15. T. b. rhodesiense: Acute or Rhodesian Sleeping Sickness
Causes acute infections in people.
Usually fatal within a year.
Occurs in native animals but it is not fatal in these animals.

16. T. b. rhodesiense: Acute or Rhodesian Sleeping Sickness
Causes acute infections in people.
Usually fatal within a year.
Occurs in native animals but it is not fatal in these animals.
Transmission by Tsetse fly.

17. T. b. rhodesiense: Acute or Rhodesian Sleeping Sickness
A more recent colonizer of people and therefore does not do well in people and kills them.

18. T. b. rhodesiense: Acute or Rhodesian Sleeping Sickness
A more recent colonizer of people and therefore does not do well in people and kills them.
It has not been around long enough to have adapted to its host (humans).

19. The Vector Glossina

20. The Vector Glossina
Biology of Glossina spp.