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Volume 11, Issue 4, Pages (April 2007)

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Presentation on theme: "Volume 11, Issue 4, Pages (April 2007)"— Presentation transcript:

1 Volume 11, Issue 4, Pages 303-305 (April 2007)
Fumarate Hydratase Deficiency and Cancer: Activation of Hypoxia Signaling?  Peter J. Ratcliffe  Cancer Cell  Volume 11, Issue 4, Pages (April 2007) DOI: /j.ccr Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Postulated Oncogenic Pathways in Cells Deficient in Fumarate Hydratase or Succinate Dehydrogenase Accumulation of the Krebs cycle intermediates fumarate and succinate is proposed to inhibit HIF hydroxylases or other 2-oxoglutarate-dependent dioxygenases, leading to upregulation of HIF or other oncogenic substrates. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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