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Mitochondrial neurogastrointestinal encephalomyopathy: Manometric and diagnostic features
Lisa A. Mueller, Michael Camilleri, Alison M. Emslie–Smith Gastroenterology Volume 116, Issue 4, Pages (April 1999) DOI: /S (99) Copyright © 1999 American Gastroenterological Association Terms and Conditions
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Fig. 1 Scintigraphic gastrointestinal transit study showing retained isotope in small bowel diverticula. Gastroenterology , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions
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Fig. 2 Manometric evaluation of stomach (sensors 1 cm apart) and small bowel (sensors 10 cm apart) showing normal-amplitude gastric antral contractions (as shown in the top three tracings labeled antroduodenum) and extremely low-amplitude or absent small bowel contractions postprandially. Gastroenterology , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions
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Fig. 3 Histological sections of a biopsy specimen taken from skeletal muscle. (A) Ragged red fiber (center field) containing subsarcolemmal accumulations of mitochondria. Most fibers are morphologically normal. (B) Two ragged blue fibers (lower left) showing marked succinate dehydrogenase overreactivity. The other fibers show normal reactivity with darker type 1 and paler type 2 fibers. (C) The same field in a consecutive section reacted to demonstrate cytochrome-c oxidase activity. Note that the ragged blue fibers are cytochrome-c oxidase negative. Three additional fibers lack cytochrome-c oxidase activity but look normal in the succinate dehydrogenase reacted section. Other fibers have normal cytochrome-c oxidase reactivity (darker type 1 fibers, paler type 2 fibers) (modified Gomori trichrome; original magnifications: A, 400×; B and C, 180×). Gastroenterology , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions
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