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MYRFs on the Move to Rewire Circuits

Published byἙκάβη Μαρής Modified over 6 years ago

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Presentation on theme: "MYRFs on the Move to Rewire Circuits"— Presentation transcript:

1 MYRFs on the Move to Rewire Circuits
Colleen N. McLaughlin, Heather T. Broihier  Developmental Cell  Volume 41, Issue 2, Pages (April 2017) DOI: /j.devcel Copyright © Terms and Conditions

2 Figure 1 Nuclear Translocation of Myrf-1 and Myrf-2 Promotes Developmental Circuit Rewiring Myrf-1 and Myrf-2 complex in the ER and subsequently undergo autocleavage to generate N- and C-terminal fragments in developing DD motoneurons. The C-terminal domains of the MYRFs remain associated with ER membrane, whereas the N-terminal domains translocate to the nucleus. Nuclear functions of the MYRF transcription factor complex drive developmental synapse remodeling. Developmental Cell  , DOI: ( /j.devcel ) Copyright © Terms and Conditions

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