1. Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.43
Figure 2 Schematic overview of the Caspr2 protein in the juxtaparanodal region of myelinated axons
Figure 2 | Schematic overview of the Caspr2 protein in the juxtaparanodal region of myelinated axons. Contactin-associated protein-like 2 (Caspr2) connects to the dimerized contactin-2 (also known as TAG-1) and to disks large homologue 4 (PSD95). This complex organizes KV1 potassium channels. Patients' antibodies bind to the extracellular region of Caspr2, possibly abrogating the Caspr2–contactin-2 interaction. ADAM22, a disintegrin and metalloproteinase 22; VGKC, voltage-gated potassium channel.
van Sonderen, A. et al. (2017) The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis
Nat. Rev. Neurol. doi: /nrneurol