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Cyclin C Makes an Entry into the Cell Cycle

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Presentation on theme: "Cyclin C Makes an Entry into the Cell Cycle"— Presentation transcript:

1 Cyclin C Makes an Entry into the Cell Cycle
Julien Sage  Developmental Cell  Volume 6, Issue 5, Pages (May 2004) DOI: /S (04)

2 Figure 1 Model for the Sequential Phosphorylation and Inactivation of Rb Family Proteins from G0 to S In response to growth factors and nutrients, Cyclin C/Cdk3 complexes become activated in G0-arrested cells and phosphorylate Rb, and potentially the two other Rb family members p107 and p130, on specific residues. Inactivation of Rb family proteins is completed in early and late G1 by phosphorylation on overlapping and additional residues by Cyclin D/Cdk4 and Cyclin E/Cdk2 complexes. Developmental Cell 2004 6, DOI: ( /S (04) )

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