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Dynein’s Life in the Slow Lane

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1 Dynein’s Life in the Slow Lane
Subhojit Roy  Neuron  Volume 90, Issue 5, Pages (June 2016) DOI: /j.neuron Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Mechanisms of Fast and Slow Axonal Transport
(A) Schematic of pulse-chase radiolabeling experiments. Note two overall rates: fast transport carrying vesicular proteins (green dots), and a slower movement carrying soluble/cytosolic and cytoskeletal proteins (orange dots and red bars, respectively; reproduced from Roy, 2014, with permission). (B) Schematic of live imaging assays to study slow transport in cultured neurons. A discrete pool of soluble/cytosolic molecules (of a given SCb protein) is optically highlighted in axons (green), and the biased dispersion of highlighted pool is recorded by live imaging. Note anterogradely biased flow of highlighted molecules (leading tip marked by red arrowhead) and corresponding anterograde shift of fluorescence center (marked by red dots and vertical dashed lines). (C) Illustrative intensity line scans of axons in (B). (D) Working models of slow and fast axonal transport. Neuron  , DOI: ( /j.neuron ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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