1. Comparison of the LL95%CI rule to PE rules with similar behaviour, when the true HR is different from the design HR: %acceptance of maximal relative benefit, over all trials, for true HR of 0.90, 0.75 and 0.65, over a range of design HRs. Annotation: Panel headers: true HR (0.65, 0.75  and 0.90) is indicated above design HR (0.65 to 0.90).
Comparison of the LL95%CI rule to PE rules with similar behaviour, when the true HR is different from the design HR: %acceptance of maximal relative benefit, over all trials, for true HR of 0.90, 0.75 and 0.65, over a range of design HRs. Annotation: Panel headers: true HR (0.65, 0.75  and 0.90) is indicated above design HR (0.65 to 0.90). Height of the bars: proportion out of the 50 000 simulated trials satisfying each condition. Grey bars: proportion of simulated trials found statistically significant (at two-sided significance level 0.05). Red, green and blue bars: %acceptance using LL95%CI ≤0.65, PE of 0.75 and 0.80, respectively. Grey-shaded areas: scenarios with design HR=true HR. Orange-shaded areas: implausible scenarios (eg, when true HR=0.65 and design HR≥0.85).
Urania Dafni et al. ESMO Open 2017;2:e000216
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