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A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size  David A. Sidloff,

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Presentation on theme: "A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size  David A. Sidloff,"— Presentation transcript:

1 A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size  David A. Sidloff, BSc (Hons), MBBS, MRCS, Philip W. Stather, MBChB, MRCS, Edward Choke, MBBS, FRCS, PhD, Matthew J. Bown, MBBCh, MD, FRCS, PGCert (Bioinformatics), Robert D. Sayers, MBChB (Hons), FRCS (Ed), FRCS (Eng), MD  Journal of Vascular Surgery  Volume 59, Issue 2, Pages e4 (February 2014) DOI: /j.jvs Copyright © 2014 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) diagram of the review. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Forest plot compares mean plasma concentration of fibrinogen between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Forest plot compares mean plasma concentration of D-dimer between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Meta-regression demonstrates the association between abdominal aortic aneurysm (AAA) diameter and D-dimer concentration. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Forest plot compares mean plasma concentration of tissue plasminogen activator (tPA) between studies. A fixed-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

7 Fig 6 Forest plot compares mean plasma concentration of thrombin-antithrombin III complex (TAT) between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

8 Fig 7 Forest plot compares mean plasma concentration of prothrombin fragments F1+F2 between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

9 Fig 8 Forest plot compares mean plasma concentration of platelet count between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

10 Supplementary Fig 1 (online only)
a, Funnel plot of studies included for meta-analysis of fibrinogen. b, Funnel plot of studies included for meta-analysis of D-dimer. c, Funnel plot of studies included for meta-analysis of tissue plasminogen activator. d, Funnel plot of studies included for meta-analysis of thrombin-antithrombin III complex (TAT). e, Funnel plot of studies included for meta-analysis of prothrombin fragments F1+F2. f, Funnel plot of studies included for meta-analysis of platelet count. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

11 Supplementary Fig 2 (online only)
Sensitivity analysis: Fibrinogen. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

12 Supplementary Fig 3 (online only)
Sensitivity analysis: D-dimer. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

13 Supplementary Fig 4 (online only)
Sensitivity analysis: Thrombin-antithrombin III complex (TAT). AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

14 Supplementary Fig 5 (online only)
Sensitivity analysis: Platelet count. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery  , e4DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

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