1. Memory: The Incomplete Unhappening of Differentiation
André Ballesteros-Tato, Troy D. Randall 
Immunity 
Volume 35, Issue 4, Pages (October 2011)
DOI: /j.immuni
Copyright © 2011 Elsevier Inc. Terms and Conditions

2. Figure 1
Opposite T Cell:DC and T Cell:B Cell Interactions Promote Tem and Tcm Cell Differentiation
After encounter with antigen-bearing DCs, naive CD4+ T cells activate and undergo expansion. Sustained interaction of T cells with DCs leads to IL-2 and IL-12-dependent T-bet upregulation and subsequent terminal Th1 cell differentiation. Sustained interaction of T cells with B cells upregulates Bcl6 and represses T-bet, which favors Tfh and Tcm cell development. After pathogen clearance, a fraction of Th1 and Tcm cells survives the contraction phase and become long-lived Tem and Tcm cells.
Immunity  , DOI: ( /j.immuni )
Copyright © 2011 Elsevier Inc. Terms and Conditions