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Evolution of extended-spectrum β-lactamases by mutation

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Presentation on theme: "Evolution of extended-spectrum β-lactamases by mutation"— Presentation transcript:

1 Evolution of extended-spectrum β-lactamases by mutation
M. Gniadkowski  Clinical Microbiology and Infection  Volume 14, Pages (January 2008) DOI: /j x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

2 Fig. 1 Tertiary structure of a class A β-lactamase with positions important for activity indicated. Reproduced with permission from Matagne et al., Biochem J 1998; 330: 581–598. © the Biochemical Society. Clinical Microbiology and Infection  , 11-32DOI: ( /j x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

3 Fig. 2 Possible pathways of evolution of TEM-type extended-spectrum β-lactamases in Poland. Reproduced with permission from Baraniak et al., Antimicrob Agents Chemother 2005; 49: 1872–1880. © American Society for Microbiology. Clinical Microbiology and Infection  , 11-32DOI: ( /j x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions


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