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RNase E Finds Some sRNAs Stimulating

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Presentation on theme: "RNase E Finds Some sRNAs Stimulating"— Presentation transcript:

1 RNase E Finds Some sRNAs Stimulating
Nicholas De Lay, Susan Gottesman  Molecular Cell  Volume 47, Issue 6, Pages (September 2012) DOI: /j.molcel Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 RNase E-Facilitated Negative Regulation of Gene Expression by sRNAs (A) Pairing of the sRNA to a region around the Shine-Dalgarno site (SD) blocks ribosome binding, allowing degradation of the mRNA; the sRNA is degraded as well. (B) The 5′-monophosphorylated sRNA pairs with the target mRNA; binding of the sRNA 5′ monophophate to RNase E stimulates cleavage of the mRNA by RNase E. The sRNA subsequently disassociates and is able to pair with an additional target mRNA before being degraded. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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