1. Volume 145, Issue 1, Pages 105-112.e15 (July 2013)
New Oral Anticoagulants Increase Risk for Gastrointestinal Bleeding: A Systematic Review and Meta-analysis 
I. Lisanne Holster, Vera E. Valkhoff, Ernst J. Kuipers, Eric T.T.L. Tjwa 
Gastroenterology 
Volume 145, Issue 1, Pages e15 (July 2013)
DOI: /j.gastro
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2. Figure 1
(A) Flowchart of included studies. (B) Indications of included studies split by drug. (C) Drugs of included studies split by indication. ∗One of these studies describes 2 subsequent trials, and therefore is mentioned twice in the data extraction. Api, apixaban; ACS, acute coronary syndrome; AF, atrial fibrillation; bet, betrixaban; dab, dabigatran; DVT, deep vein thrombosis; edo, edoxaban; Med ill, medically ill; OS, orthopedic surgery; PE, pulmonary embolism; riv, rivaroxaban.
Gastroenterology  , e15DOI: ( /j.gastro )
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3. Figure 2
(A) Forrest plot of GIB with subgroup analysis by indication. (B) Forrest plot of GIB with subgroup analysis by drug. Data are presented as OR (95% CI) using a random-effects model and I2 test for heterogeneity. Api, apixaban; bet, betrixaban; dab, dabigatran; edo, edoxaban; riv, rivaroxaban; ACS, acute coronary syndrome; AF, atrial fibrillation; DVT, deep vein thrombosis; Med ill, medically ill; OS, orthopedic surgery; PE, pulmonary embolism.
Gastroenterology  , e15DOI: ( /j.gastro )
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4. Figure 3
Forrest plot of clinically relevant bleeding summarized by indication and by drug. Data are presented as OR (95% CI) using a random effects model and an I2 test for heterogeneity. ACS, acute coronary syndrome; AF, atrial fibrillation; DVT, deep vein thrombosis; Med ill, medically ill; OS, orthopedic surgery; PE, pulmonary embolism.
Gastroenterology  , e15DOI: ( /j.gastro )
Copyright © 2013 AGA Institute Terms and Conditions

5. Supplementary Figure 1 Funnel plot of publication bias.
Gastroenterology  , e15DOI: ( /j.gastro )
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